Title : PDK1 recruitment to the SHPS-1 signaling complex enhances insulin-like growth factor-i-stimulated AKT activation and vascular smooth muscle cell survival.

Pub. Date : 2010 Sep 17

PMID : 20643654






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 A proline-rich sequence in PDK1 bound to an Src homology 3 domain in Grb2 in response to IGF-I. Proline growth factor receptor bound protein 2 Homo sapiens
2 Disruption of Grb2-PDK1 by expression of either a Grb2 Src homology 3 domain or a PDK1 proline to alanine mutant inhibited PDK1 recruitment to SHPS-1, leading to impaired IGF-I-stimulated AKT Thr(308) phosphorylation. Proline growth factor receptor bound protein 2 Homo sapiens