Title : Phosphorylation of the von Hippel-Lindau protein (VHL) by protein kinase CK2 reduces its protein stability and affects p53 and HIF-1alpha mediated transcription.

Pub. Date : 2010 Oct

PMID : 20637892






2 Functional Relationships(s)
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1 By using 4,5,6,7-tetrabromobenzotriazole (TBB), a CK2-specific inhibitor, as well as a mutant VHL where serines 33, 38 and 43 were replaced by alanines we found that CK2 phosphorylation affected the VHL protein half-life and increased VHL protein stability. 4,5,6,7-tetrabromobenzotriazole von Hippel-Lindau tumor suppressor Homo sapiens
2 By using 4,5,6,7-tetrabromobenzotriazole (TBB), a CK2-specific inhibitor, as well as a mutant VHL where serines 33, 38 and 43 were replaced by alanines we found that CK2 phosphorylation affected the VHL protein half-life and increased VHL protein stability. 4,5,6,7-tetrabromobenzotriazole von Hippel-Lindau tumor suppressor Homo sapiens