Title : On the dependence of spontaneous mutation rates on the functional state of genes.

Pub. Date : 1991 Feb

PMID : 2063623






1 Functional Relationships(s)
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1 It was shown that a decrease in the amount of adenine (from 500 to 0 mg l-1) or leucine (from 300 to 0.3 mg l-1) in the medium, simultaneously with the transition from repression to derepression of the biosynthesis of these metabolites, resulted in a 15- to 150-fold increase in the reversion rate of genes ade 2 and leu2, respectively, for different strains. Leucine 3-isopropylmalate dehydrogenase Saccharomyces cerevisiae S288C