Title : A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs.

Pub. Date : 2010 Sep

PMID : 20633676






1 Functional Relationships(s)
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1 METHODS: Monosodium iodoacetate (MIA), a metabolic inhibitor, was injected into the right knee joint of male Lewis rats and the release of aggrecanase-cleaved fragments of aggrecan containing the NITEGE or ARGN neoepitope was measured in the synovial fluid at 7 days post MIA injection using novel ELISAs. monosodium iodoacetate ADAM metallopeptidase with thrombospondin type 1 motif, 4 Rattus norvegicus