Title : Involvement of xanthine oxidase and hypoxia-inducible factor 1 in Toll-like receptor 7/8-mediated activation of caspase 1 and interleukin-1β.

Pub. Date : 2011 Jan

PMID : 20632067






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 XOD produces uric acid and reactive oxygen species, which could activate Nalp3 and therefore induce activation of caspase 1, known to convert inactive pro-IL-1beta into active IL-1beta. Reactive Oxygen Species NLR family pyrin domain containing 3 Homo sapiens