Pub. Date : 2010 Oct
PMID : 20631054
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of epigenetic mechanisms in differential regulation of the dioxin-inducible human CYP1A1 and CYP1B1 genes. | Dioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 2 | The aryl hydrocarbon receptor (AhR) mediates induction of CYP1A1 and CYP1B1 by 2,3,7,8-tetrachlorodibenzo-rho-dioxin (dioxin) via binding to xenobiotic-responsive elements (XREs) in their enhancer regions. | Dioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 3 | CYP1A1 and CYPIB1 were both inducible by dioxin in human MCF-7 cells. | Dioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 4 | Dioxin induced the recruitment of AHR and the transcriptional coactivators p300 and p300/cAMP response element-binding protein binding protein-associated factor (PCAF) to the CYP1B1 enhancer in HepG2 cells but failed to induce recruitment of RNA polymerase II (polII) or the TATA binding protein (TBP) and acetylations of histones 3 and 4 or methylation of histone 3 at the promoter. | Dioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |
| 5 | Because p300 was required for dioxin induction of the aforementioned histone modifications at the CYP1B1 promoter and for induction of CYP1B1 transcription (in MCF-7 cells), the recruitments of p300 and AhR, although necessary, are not sufficient for eliciting the above responses to dioxin. | Dioxins | cytochrome P450 family 1 subfamily B member 1 | Homo sapiens |