Title : Impact of ATP-binding cassette, subfamily B, member 1 pharmacogenetics on tacrolimus-associated nephrotoxicity and dosage requirements in paediatric patients with liver transplant.

Pub. Date : 2011 Jan

PMID : 20629603






6 Functional Relationships(s)
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1 Impact of ATP-binding cassette, subfamily B, member 1 pharmacogenetics on tacrolimus-associated nephrotoxicity and dosage requirements in paediatric patients with liver transplant. Tacrolimus ATP binding cassette subfamily B member 1 Homo sapiens
2 Studies examining interindividual differences in the expression of the ABCB1 (ATP-binding cassette, subfamily B, member 1) gene (which encodes the drug transporter, P-gp) and its genetic polymorphisms have attempted to elucidate variations in tacrolimus response and disposition in children. Tacrolimus ATP binding cassette subfamily B member 1 Homo sapiens
3 Studies examining interindividual differences in the expression of the ABCB1 (ATP-binding cassette, subfamily B, member 1) gene (which encodes the drug transporter, P-gp) and its genetic polymorphisms have attempted to elucidate variations in tacrolimus response and disposition in children. Tacrolimus ATP binding cassette subfamily B member 1 Homo sapiens
4 AREAS COVERED IN THIS REVIEW: This review explores pharmacogenetic knowledge developed over the last decade regarding the impact of ABCB1 polymorphisms on tacrolimus toxicity and dosage requirements in children. Tacrolimus ATP binding cassette subfamily B member 1 Homo sapiens
5 WHAT THE READER WILL GAIN: A better understanding of the role of ABCB1 genetic polymorphisms (and corresponding haplotypes) and ABCB1 expression levels in various tissues and organs on tacrolimus outcomes in children with liver transplant. Tacrolimus ATP binding cassette subfamily B member 1 Homo sapiens
6 WHAT THE READER WILL GAIN: A better understanding of the role of ABCB1 genetic polymorphisms (and corresponding haplotypes) and ABCB1 expression levels in various tissues and organs on tacrolimus outcomes in children with liver transplant. Tacrolimus ATP binding cassette subfamily B member 1 Homo sapiens