Pub. Date : 2011 Jan
PMID : 20629603
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Impact of ATP-binding cassette, subfamily B, member 1 pharmacogenetics on tacrolimus-associated nephrotoxicity and dosage requirements in paediatric patients with liver transplant. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Studies examining interindividual differences in the expression of the ABCB1 (ATP-binding cassette, subfamily B, member 1) gene (which encodes the drug transporter, P-gp) and its genetic polymorphisms have attempted to elucidate variations in tacrolimus response and disposition in children. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Studies examining interindividual differences in the expression of the ABCB1 (ATP-binding cassette, subfamily B, member 1) gene (which encodes the drug transporter, P-gp) and its genetic polymorphisms have attempted to elucidate variations in tacrolimus response and disposition in children. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | AREAS COVERED IN THIS REVIEW: This review explores pharmacogenetic knowledge developed over the last decade regarding the impact of ABCB1 polymorphisms on tacrolimus toxicity and dosage requirements in children. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | WHAT THE READER WILL GAIN: A better understanding of the role of ABCB1 genetic polymorphisms (and corresponding haplotypes) and ABCB1 expression levels in various tissues and organs on tacrolimus outcomes in children with liver transplant. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | WHAT THE READER WILL GAIN: A better understanding of the role of ABCB1 genetic polymorphisms (and corresponding haplotypes) and ABCB1 expression levels in various tissues and organs on tacrolimus outcomes in children with liver transplant. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |