Title : Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.

Pub. Date : 2010 Aug 1

PMID : 20624682






1 Functional Relationships(s)
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1 This change led to a steady increase of 16% of the catalytic activity of the mutant hCA I over the wild type enzyme, which is a gain of 50% catalytic efficiency if one compares hCA I and hCA II as catalysts for CO(2) hydration. co(2) cytochrome P450 family 24 subfamily A member 1 Homo sapiens