Pub. Date : 2010 Sep 29
PMID : 20620199
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic inactivation of pleiotrophin triggers amphetamine-induced cell loss in the substantia nigra and enhances amphetamine neurotoxicity in the striatum. | Amphetamine | pleiotrophin | Mus musculus |
| 2 | Genetic inactivation of pleiotrophin triggers amphetamine-induced cell loss in the substantia nigra and enhances amphetamine neurotoxicity in the striatum. | Amphetamine | pleiotrophin | Mus musculus |
| 3 | To test this hypothesis, we have studied the effects of amphetamine (10 mg/kg, four times, every 2 h) on the nigrostriatal pathway of PTN genetically deficient (PTN-/-) mice. | Amphetamine | pleiotrophin | Mus musculus |
| 4 | We found that amphetamine causes a significantly enhanced loss of dopaminergic terminals in the striatum of PTN-/- mice compared to wild type (WT+/+) mice. | Amphetamine | pleiotrophin | Mus musculus |
| 5 | In addition, we found a significant decrease ( approximately 20%) of tyrosine hydroxylase (TH)-positive neurons only in the substantia nigra of amphetamine-treated PTN-/- mice, whereas this area of WT+/+ animals remained unaffected after amphetamine treatment. | Amphetamine | pleiotrophin | Mus musculus |
| 6 | This effect was accompanied by enhanced amphetamine-induced astrocytosis in the substantia nigra of PTN-/- mice. | Amphetamine | pleiotrophin | Mus musculus |
| 7 | The data suggest an important role of PTN in the protection of nigrostriatal pathways against amphetamine insult. | Amphetamine | pleiotrophin | Mus musculus |