Title : Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease.

Pub. Date : 2010 Aug 1

PMID : 20620068






1 Functional Relationships(s)
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1 The most effective BACE 1 inhibitor 9f (27.85+/-2.46 micromol/L) was selected for further receptor-binding studies, the result of which indicated that an essential hydrogen bonds was formed between the urea group of 9f and the catalytic aspartate Asp228. Hydrogen beta-secretase 1 Homo sapiens