Title : A new cyclooxygenase-2 inhibitor, (1E,4E)-1,5-bis(2-bromophenyl)penta-1,4-dien-3-one (GL63) suppresses cyclooxygenase-2 gene expression in human lung epithelial cancer cells: coupled mRNA stabilization and posttranscriptional inhibition.

Pub. Date : 2010

PMID : 20606309






5 Functional Relationships(s)
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1 In this study, the effect of curcumin and curcumin analogues on COX-2 expression induced by phorbol 12-myristate 13-acetate (PMA) were investigated. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
2 In this study, the effect of curcumin and curcumin analogues on COX-2 expression induced by phorbol 12-myristate 13-acetate (PMA) were investigated. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
3 We found that a novel curcumin analogue (GL63) inhibited PMA-induced COX-2 mRNA and protein levels in H460 cells to a greater degree than curcumin. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
4 Taken together, our results provide evidence that the novel curcumin analogue can effectively inhibit PMA-induced COX-2 expression in H460 cells, a mechanism associated with COX-2 mRNA stability and post-transcriptional regulation. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens
5 Taken together, our results provide evidence that the novel curcumin analogue can effectively inhibit PMA-induced COX-2 expression in H460 cells, a mechanism associated with COX-2 mRNA stability and post-transcriptional regulation. Tetradecanoylphorbol Acetate prostaglandin-endoperoxide synthase 2 Homo sapiens