Title : Effect of maceligan on the systemic exposure of paclitaxel: in vitro and in vivo evaluation.

Pub. Date : 2010 Oct 9

PMID : 20600879






2 Functional Relationships(s)
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1 The inhibition effect of macelignan on the CYP3A4-mediated metabolism was negligible over the concentration range of 0.01-100muM in rat liver microsome while approximately 33% inhibition was observed at 100muM in human liver microsome, implying that the interaction of macelignan with CYP3A4 might be insignificant at the physiologically achievable concentrations. macelignan cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 The inhibition effect of macelignan on the CYP3A4-mediated metabolism was negligible over the concentration range of 0.01-100muM in rat liver microsome while approximately 33% inhibition was observed at 100muM in human liver microsome, implying that the interaction of macelignan with CYP3A4 might be insignificant at the physiologically achievable concentrations. macelignan cytochrome P450 family 3 subfamily A member 4 Homo sapiens