Title : Improved cardiac performance by rosuvastatin is associated with attenuations in both myocardial tumor necrosis factor-alpha and p38 MAP kinase activity in rats after myocardial infarction.

Pub. Date : 2010 Aug

PMID : 20588182






3 Functional Relationships(s)
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1 Improved cardiac performance by rosuvastatin is associated with attenuations in both myocardial tumor necrosis factor-alpha and p38 MAP kinase activity in rats after myocardial infarction. Rosuvastatin Calcium tumor necrosis factor Rattus norvegicus
2 Moreover, treatment of rosuvastatin markedly improved ventricular remodeling and cardiac function in rats, which was associated with attenuations in both TNF-alpha gene expression and p38 MAP kinase activity in myocardium without changes in serum lipid levels. Rosuvastatin Calcium tumor necrosis factor Rattus norvegicus
3 CONCLUSIONS: Treatment of rosuvastatin was able to improve cardiac remodeling and cardiac function after acute MI, which was associated with attenuations in both expression of TNF-alpha and activity of p38 MAP kinase in myocardium. Rosuvastatin Calcium tumor necrosis factor Rattus norvegicus