Title : The pan-Bcl-2 inhibitor (-)-gossypol triggers autophagic cell death in malignant glioma.

Pub. Date : 2010 Jul

PMID : 20587533






1 Functional Relationships(s)
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1 Lentiviral knockdown of Beclin1 and Atg5 in U87, U343, and MZ-54 cells strongly diminished the extent of cell death induced by (-)-gossypol and combined treatment with TMZ, indicating that autophagy contributed to this type of cell death. Gossypol autophagy related 5 Homo sapiens