Title : Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex.

Pub. Date : 2010 Aug

PMID : 20581821






4 Functional Relationships(s)
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1 Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. catechol lipocalin 2 Homo sapiens
2 Using chemical screens, crystallography and fluorescence methods, we report that Scn-Ngal binds iron together with a small metabolic product called catechol. catechol lipocalin 2 Homo sapiens
3 As catechols derive from bacterial and mammalian metabolism of dietary compounds, the Scn-Ngal-catechol-Fe(III) complex represents an unforeseen microbial-host interaction, which mimics Scn-Ngal-siderophore interactions but instead traffics iron in aseptic tissues. catechol lipocalin 2 Homo sapiens
4 As catechols derive from bacterial and mammalian metabolism of dietary compounds, the Scn-Ngal-catechol-Fe(III) complex represents an unforeseen microbial-host interaction, which mimics Scn-Ngal-siderophore interactions but instead traffics iron in aseptic tissues. catechol lipocalin 2 Homo sapiens