Title : Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.

Pub. Date : 2010 Oct 7

PMID : 20576813






1 Functional Relationships(s)
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1 CK2 inhibitors (4,5,6,7-tetrabromo-1H-benzotriazole, apigenin, and 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazol) decreased phosphorylation of PTEN and Akt, induced apoptosis in CLL cells, and enhanced the response to fludarabine. 2-ethylhexyl 2,3,4,5-tetrabromobenzoate AKT serine/threonine kinase 1 Homo sapiens