Title : The osteoconductivity of biomaterials is regulated by bone morphogenetic protein 2 autocrine loop involving α2β1 integrin and mitogen-activated protein kinase/extracellular related kinase signaling pathways.

Pub. Date : 2010 Oct

PMID : 20575676






1 Functional Relationships(s)
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1 Culturing human osteoblasts on beta-TCP scaffold for 1 and 7 days induced gene expression of bone morphogenetic protein 2 (BMP2) and its receptors and activated its downstream Smad1/5 signaling pathway, which were orchastrated with induced osteoblastic differentiation. beta-tricalcium phosphate SMAD family member 1 Homo sapiens