Title : Low-GDP peritoneal dialysis fluid ('balance') has less impact in vitro and ex vivo on epithelial-to-mesenchymal transition (EMT) of mesothelial cells than a standard fluid.

Pub. Date : 2011 Jan

PMID : 20571097






2 Functional Relationships(s)
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1 This could be confirmed ex vivo, as the prevalence of non-epitheloid phenotype of MC in the standard group was significantly higher with increasing PD duration and MC isolated from this group showed significantly higher levels of EMT-associated molecules including fibronectin, collagen I, VEGF, IL-8 and TGF-beta levels when compared with the low-GDP group. Methylcholanthrene C-X-C motif chemokine ligand 8 Homo sapiens
2 Accordingly, effluent MC with non-epitheloid morphology showed significantly lower levels of E-cadherin and greater levels of fibronectin, collagen I, VEGF and IL 8 when compared with MC with epitheloid phenotype. Methylcholanthrene C-X-C motif chemokine ligand 8 Homo sapiens