Pub. Date : 2010 Aug 20
PMID : 20566634
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways. | arsenite | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 2 | In this study, we found that depletion of p27 expression by either gene knock-out or knockdown approaches resulted in up-regulation of both Hsp27 and Hsp70 expression at mRNA- and promoter-derived transcription as well as protein levels upon arsenite exposure, indicating that p27 provides a negative signal for regulating the expression of Hsp27 and Hsp70. | arsenite | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 3 | Moreover, interference with the expression or function of JNK2, c-Jun, and HSF-1, but not JNK1, led to dramatic inhibition of arsenite-induced Hsp27 and Hsp70 expression. | arsenite | heat shock protein family A (Hsp70) member 4 | Homo sapiens |
| 4 | Collectively, our results demonstrate that p27 suppresses Hsp27 and Hsp70 expression at the transcriptional level specifically through JNK2/c-Jun- and HSF-1-dependent pathways upon arsenite exposure, which provides additional important molecular mechanisms for the tumor-suppressive function of p27. | arsenite | heat shock protein family A (Hsp70) member 4 | Homo sapiens |