Title : P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain.

Pub. Date : 2010 Jul 21

PMID : 20562826






1 Functional Relationships(s)
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1 Stimulating P2X4R in macrophages triggers calcium influx and p38 MAPK phosphorylation, resulting in cytosolic PLA2 (cPLA2) activation and COX-dependent release of PGE2. Dinoprostone mitogen-activated protein kinase 14 Mus musculus