Title : Methylphenidate affects memory, brain-derived neurotrophic factor immunocontent and brain acetylcholinesterase activity in the rat.

Pub. Date : 2010 Sep

PMID : 20561592






2 Functional Relationships(s)
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1 A reduction on brain-derived neurotrophic factor immunocontent and increased acetylcholinesterase activity in prefrontal cortex, but not in hippocampus, of rats treated with methylphenidate were also observed. Methylphenidate acetylcholinesterase Rattus norvegicus
2 These results suggest that the deficit in spatial memory may be associated to decreased brain-derived neurotrophic factor immunocontent and increased acetylcholinesterase in prefrontal cortex of juvenile rats subjected to methylphenidate administration. Methylphenidate acetylcholinesterase Rattus norvegicus