Title : Conversion of growth hormone-secreting cells into prolactin-secreting cells and its promotion by insulin and insulin-like growth factor-1 in vitro.

Pub. Date : 1991 Jul

PMID : 2055276






7 Functional Relationships(s)
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1 The newly established rat pituitary cell line, MtT/S, has pituitary somatotroph (growth hormone-producing cell)-like characteristics, i.e., the cells produce growth hormone (GH), possess GH-immunopositive secretory granules, and respond to GH-releasing hormone. monooxyethylene trimethylolpropane tristearate gonadotropin releasing hormone receptor Rattus norvegicus
2 The newly established rat pituitary cell line, MtT/S, has pituitary somatotroph (growth hormone-producing cell)-like characteristics, i.e., the cells produce growth hormone (GH), possess GH-immunopositive secretory granules, and respond to GH-releasing hormone. monooxyethylene trimethylolpropane tristearate gonadotropin releasing hormone receptor Rattus norvegicus
3 The newly established rat pituitary cell line, MtT/S, has pituitary somatotroph (growth hormone-producing cell)-like characteristics, i.e., the cells produce growth hormone (GH), possess GH-immunopositive secretory granules, and respond to GH-releasing hormone. monooxyethylene trimethylolpropane tristearate gonadotropin releasing hormone receptor Rattus norvegicus
4 The newly established rat pituitary cell line, MtT/S, has pituitary somatotroph (growth hormone-producing cell)-like characteristics, i.e., the cells produce growth hormone (GH), possess GH-immunopositive secretory granules, and respond to GH-releasing hormone. monooxyethylene trimethylolpropane tristearate gonadotropin releasing hormone receptor Rattus norvegicus
5 The newly established rat pituitary cell line, MtT/S, has pituitary somatotroph (growth hormone-producing cell)-like characteristics, i.e., the cells produce growth hormone (GH), possess GH-immunopositive secretory granules, and respond to GH-releasing hormone. monooxyethylene trimethylolpropane tristearate gonadotropin releasing hormone receptor Rattus norvegicus
6 These results show that insulin and IGF-1 stimulate conversion of MtT/S cell line GH cells to PRL cells. monooxyethylene trimethylolpropane tristearate gonadotropin releasing hormone receptor Rattus norvegicus
7 This suggests that the MtT/S cell line is an excellent model system which shows the GH-cell/PRL-cell lineage. monooxyethylene trimethylolpropane tristearate gonadotropin releasing hormone receptor Rattus norvegicus