Title : Passive diffusion of acetylcholinesterase oxime reactivators through the blood-brain barrier: influence of molecular structure.

Pub. Date : 2010 Sep

PMID : 20546883






1 Functional Relationships(s)
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1 The location of groups on the pyridine ring also influences passive transport into the brain; the optimum position of the oxime group was found to be position four (para) and substitution of the oxime group on the pyridine ring by carbamoyl or amidoxime group markedly decreased penetration of AChE reactivators into the CNS. pyridine acetylcholinesterase (Cartwright blood group) Homo sapiens