Pub. Date : 2010 Sep 30
PMID : 20543519
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both TG content and ApoB-48 mass were decreased in ezetimibe-treated mice. | Ezetimibe | apolipoprotein B | Mus musculus |
| 2 | The quantitative RT-PCR of intestinal mucosa showed down-regulation of the mRNA expression of FATP4 and ApoB in both groups along with FABP2, DGAT1, DGAT2 and SCD1 in WT mice at postprandial state after ezetimibe treatment. | Ezetimibe | apolipoprotein B | Mus musculus |
| 3 | CONCLUSION: Ezetimibe alone reduces PHTG by blocking both the absorption of cholesterol and the intracellular trafficking and metabolism of long-chain fatty acids in enterocytes, resulting in the reduction of the formation of ApoB-48 which is necessary for the ApoB48-containing lipoprotein production in the small intestines. | Ezetimibe | apolipoprotein B | Mus musculus |
| 4 | CONCLUSION: Ezetimibe alone reduces PHTG by blocking both the absorption of cholesterol and the intracellular trafficking and metabolism of long-chain fatty acids in enterocytes, resulting in the reduction of the formation of ApoB-48 which is necessary for the ApoB48-containing lipoprotein production in the small intestines. | Ezetimibe | apolipoprotein B | Mus musculus |