Pub. Date : 2011 Mar 15
PMID : 20542267
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Heparin inhibits interferon-gamma signaling in human endometrial stromal cells by interference with the cellular binding of interferon-gamma. | Heparin | interferon gamma | Homo sapiens |
| 2 | Heparin inhibits interferon-gamma signaling in human endometrial stromal cells by interference with the cellular binding of interferon-gamma. | Heparin | interferon gamma | Homo sapiens |
| 3 | OBJECTIVE: To examine the impact of heparins on interferon-gamma (IFN-gamma) signaling in human endometrial stromal cells (ESCs) in vitro. | Heparin | interferon gamma | Homo sapiens |
| 4 | OBJECTIVE: To examine the impact of heparins on interferon-gamma (IFN-gamma) signaling in human endometrial stromal cells (ESCs) in vitro. | Heparin | interferon gamma | Homo sapiens |
| 5 | RESULT(S): Heparin and LMWHs inhibit the IFN-gamma-mediated induction of IRF-1, but not Nmi in undifferentiated and decidualized ESCs. | Heparin | interferon gamma | Homo sapiens |
| 6 | Heparin has no effect on the IFN-gamma receptor in ESCs, but inhibits the binding of IFN-gamma to the cells. | Heparin | interferon gamma | Homo sapiens |
| 7 | CONCLUSION(S): Unfractionated heparin, as well as LMWHs, are able to inhibit IFN-gamma signaling in human ESCs and therefore might be clinically interesting agents to modulate the actions of this proinflammatory cytokine at the implantation site. | Heparin | interferon gamma | Homo sapiens |