Title : Genotoxic polycyclic aromatic hydrocarbons fail to induce the p53-dependent DNA damage response, apoptosis or cell-cycle arrest in human prostate carcinoma LNCaP cells.

Pub. Date : 2010 Sep 1

PMID : 20542099






1 Functional Relationships(s)
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1 When analyzing the effect of BaP on the induction of CYP1 enzymes participating in the metabolic activation of PAHs in LNCaP cells, we found that BaP induced expression of CYP1A1 and CYP1A2, but not CYP1B1 enzyme. Benzo(a)pyrene cytochrome P450 family 1 subfamily A member 2 Homo sapiens