Pub. Date : 2010 Jul 30
PMID : 20542014
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We report that rapamycin (2.5muM), significantly increases Abeta generation in murine neuron-like cells (N2a) transfected with the human "Swedish" mutant amyloid precursor protein (APP). | Sirolimus | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | injected Tg2576 Abeta-overproducing transgenic mice with rapamycin (3mg/kg/day) for 2weeks. | Sirolimus | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | We found increased Abeta levels associated with decreased sAPP-alpha at an average rapamycin plasma concentration of 169.7+/-23.5ng/mL by high performance liquid chromatography (HPLC). | Sirolimus | amyloid beta (A4) precursor protein | Mus musculus |