Title : Carnitine palmitoyltransferase 2: New insights on the substrate specificity and implications for acylcarnitine profiling.

Pub. Date : 2010 Sep

PMID : 20538056






2 Functional Relationships(s)
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1 We show that CPT2 is active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters, whereas virtually no activity was found with short- and very long-chain acyl-CoAs or with branched-chain amino acid oxidation intermediates. Acyl Coenzyme A carnitine palmitoyltransferase 2 Homo sapiens
2 The results obtained clearly demonstrate that CPT2 is able to reverse its physiological mechanism for medium and long-chain acyl-CoAs contributing to the abnormal acylcarnitines profiles characteristic of most mFAO disorders. Acyl Coenzyme A carnitine palmitoyltransferase 2 Homo sapiens