Title : Zinc is not required for activity of TPO agonists acting at the c-Mpl receptor transmembrane domain.

Pub. Date : 2010 Aug 20

PMID : 20536264






1 Functional Relationships(s)
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1 Using addition of zinc and a potent metal chelator, we show that the existing paradigm is incorrect and the compounds exhibit excellent thrombopoietin-mimetic activity even in the presence of high concentrations of EDTA. Edetic Acid thrombopoietin Homo sapiens