Title : Unexpected enhancement in biological activity of a GPCR ligand induced by an oligoethylene glycol substituent.

Pub. Date : 2010 Jul 7

PMID : 20536128






2 Functional Relationships(s)
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1 Our investigation of formyl peptide receptor (FPR)-mediated chemotaxis reveals that oligoethylene glycol substitution can enhance the ability of the peptide chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLF) to activate signal transduction through FPR, a transmembrane G-protein-coupled receptor. N-Formylmethionine Leucyl-Phenylalanine formyl peptide receptor 1 Homo sapiens
2 Our investigation of formyl peptide receptor (FPR)-mediated chemotaxis reveals that oligoethylene glycol substitution can enhance the ability of the peptide chemoattractant N-formyl-methionine-leucine-phenylalanine (fMLF) to activate signal transduction through FPR, a transmembrane G-protein-coupled receptor. N-Formylmethionine Leucyl-Phenylalanine formyl peptide receptor 1 Homo sapiens