Title : Profound hypocalcemia following effective response to zoledronic acid treatment in a patient with juvenile Paget's disease.

Pub. Date : 2010 Nov

PMID : 20533067






1 Functional Relationships(s)
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1 Compared with other BPs, zoledronic acid (ZOL) has a higher affinity to bone mineral and is a stronger inhibitor of the enzyme farnesyl pyrophosphate synthase (the main target of nitrogen-containing BPs), properties that explain the prolonged effect of ZOL on bone turnover and render it a therapeutic option for JPD, similar to PDB. Diphosphonates farnesyl diphosphate synthase Homo sapiens