Title : Mutant huntingtin-impaired degradation of beta-catenin causes neurotoxicity in Huntington's disease.

Pub. Date : 2010 Jul 21

PMID : 20531388






2 Functional Relationships(s)
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1 As a consequence, the beta-transducin repeat-containing protein (beta-TrCP) rescues polyglutamine (polyQ)-huntingtin-induced toxicity in striatal neurons and in a Drosophila model of HD, through the specific degradation of beta-catenin. polyglutamine huntingtin Drosophila melanogaster
2 As a consequence, the beta-transducin repeat-containing protein (beta-TrCP) rescues polyglutamine (polyQ)-huntingtin-induced toxicity in striatal neurons and in a Drosophila model of HD, through the specific degradation of beta-catenin. polyglutamine huntingtin Drosophila melanogaster