Pub. Date : 2010 Aug 19
PMID : 20531297
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting the receptor tyrosine kinase RET sensitizes breast cancer cells to tamoxifen treatment and reveals a role for RET in endocrine resistance. | Tamoxifen | ret proto-oncogene | Homo sapiens |
| 2 | In tamoxifen response experiments, RET downregulation resulted in 6.2-fold increase in sensitivity of MCF7 cells to antiproliferative effects of tamoxifen, whereas GDNF stimulation had a protective effect against the drug. | Tamoxifen | ret proto-oncogene | Homo sapiens |
| 3 | In tamoxifen response experiments, RET downregulation resulted in 6.2-fold increase in sensitivity of MCF7 cells to antiproliferative effects of tamoxifen, whereas GDNF stimulation had a protective effect against the drug. | Tamoxifen | ret proto-oncogene | Homo sapiens |
| 4 | In tamoxifen-resistant (TAM(R)-1) MCF7 cells, targeting RET restored tamoxifen sensitivity. | Tamoxifen | ret proto-oncogene | Homo sapiens |
| 5 | In tamoxifen-resistant (TAM(R)-1) MCF7 cells, targeting RET restored tamoxifen sensitivity. | Tamoxifen | ret proto-oncogene | Homo sapiens |
| 6 | Finally, examination of two independent tissue microarrays of primary human breast cancers revealed that expression of RET protein was significantly associated with ERalpha-positive tumors and that in primary tumors from patients who subsequently developed invasive recurrence after adjuvant tamoxifen treatment, there was a twofold increase in the number of RET-positive tumors. | Tamoxifen | ret proto-oncogene | Homo sapiens |
| 7 | Finally, examination of two independent tissue microarrays of primary human breast cancers revealed that expression of RET protein was significantly associated with ERalpha-positive tumors and that in primary tumors from patients who subsequently developed invasive recurrence after adjuvant tamoxifen treatment, there was a twofold increase in the number of RET-positive tumors. | Tamoxifen | ret proto-oncogene | Homo sapiens |
| 8 | Together these findings identify RET as a potentially important therapeutic target in ERalpha-positive breast cancers and in particular in tamoxifen-resistant tumors. | Tamoxifen | ret proto-oncogene | Homo sapiens |