Title : Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries.

Pub. Date : 2010 Jul 23

PMID : 20522806






1 Functional Relationships(s)
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1 METHODS AND RESULTS: After NO synthase inhibition (L-NAME), thrombin contracted aged arteries, which was inhibited by endothelial denudation, ET(A) receptor antagonism (BQ123), and ECE inhibition (phosphoramidon, SM19712) or by inhibiting exocytosis (TAT-NSF, N-ethylmaleimide-sensitive factor inhibitor). phosphoramidon coagulation factor II, thrombin Homo sapiens