Title : Amino acids stimulate Akt phosphorylation, and reduce IL-8 production and NF-κB activity in HepG2 liver cells.

Pub. Date : 2010 Nov

PMID : 20512787






2 Functional Relationships(s)
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1 After 24 h, glutamine inhibited IL-8 production significantly (p<0.05) at 2, 5 and 10 mM (to 82, 73 and 72% of control), whereas leucine reduced IL-8 production significantly only at 10 mM (66%) and proline at 5 and 10 mM (71 and 52%). Leucine C-X-C motif chemokine ligand 8 Homo sapiens
2 Our results indicate that glutamine, leucine and proline attenuate IL-8 production, probably through inhibition of NF-kappaB, and that they increase Akt phosphorylation in HepG2 cells. Leucine C-X-C motif chemokine ligand 8 Homo sapiens