Title : Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds.

Pub. Date : 2010 Sep 15

PMID : 20510679






3 Functional Relationships(s)
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1 In the present study, reactivation kinetics of tabun-, sarin-, cyclosarin-, VX- or paraoxon-ethyl-inhibited human AChE (hAChE) with a homologous series of bis-ortho-pyridiniumaldoximes, Ortho-4 - Ortho-9, was investigated with a robot-assisted setting, allowing determination of second-order reactivation rate constants as well as model calculations. cyclohexyl methylphosphonofluoridate acetylcholinesterase (Cartwright blood group) Homo sapiens
2 In the present study, reactivation kinetics of tabun-, sarin-, cyclosarin-, VX- or paraoxon-ethyl-inhibited human AChE (hAChE) with a homologous series of bis-ortho-pyridiniumaldoximes, Ortho-4 - Ortho-9, was investigated with a robot-assisted setting, allowing determination of second-order reactivation rate constants as well as model calculations. cyclohexyl methylphosphonofluoridate acetylcholinesterase (Cartwright blood group) Homo sapiens
3 In contrast, k(r) decreased with increasing linker length for sarin- and cyclosarin-inhibited hAChE. cyclohexyl methylphosphonofluoridate acetylcholinesterase (Cartwright blood group) Homo sapiens