Title : Up-regulation of connexin 32 gene by 5-aza-2'-deoxycytidine enhances vinblastine-induced cytotoxicity in human renal carcinoma cells via the activation of JNK signalling.

Pub. Date : 2010 Aug 15

PMID : 20510207






1 Functional Relationships(s)
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1 Moreover, increased transcription activity of c-Jun by the JNK activation contributed to the down-regulation of MDR1, thus indicating a central role of JNK signalling to suppress P-gp level in 5-Aza-treated Caki-1 cells. Azathioprine Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens