Title : Molecular and cellular events of dopamine D1 receptor-mediated tau phosphorylation in SK-N-MC cells.

Pub. Date : 2011 Jan

PMID : 20506302






2 Functional Relationships(s)
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1 Using selective pharmacological tools, we showed that enhanced intracellular calcium lead to cyclin-dependent kinase 5 (cdk5) activation, by calpain proteolysis of p35 to p25, as well as glycogen synthase kinase 3beta (GSK3beta) activation, by its phosphorylation at tyrosine 216. Calcium cyclin dependent kinase 5 Homo sapiens
2 Using selective pharmacological tools, we showed that enhanced intracellular calcium lead to cyclin-dependent kinase 5 (cdk5) activation, by calpain proteolysis of p35 to p25, as well as glycogen synthase kinase 3beta (GSK3beta) activation, by its phosphorylation at tyrosine 216. Calcium cyclin dependent kinase 5 Homo sapiens