Title : Pralatrexate is synergistic with the proteasome inhibitor bortezomib in in vitro and in vivo models of T-cell lymphoid malignancies.

Pub. Date : 2010 Jul 15

PMID : 20501616






1 Functional Relationships(s)
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1 PURPOSE: Pralatrexate (10-propargyl-10-deazaaminopterin) is an antifolate with improved cellular uptake and retention due to greater affinity for the reduced folate carrier (RFC-1) and folyl-polyglutamyl synthase. Folic Acid replication factor C subunit 1 Homo sapiens