Pub. Date : 2010 Sep
PMID : 20493916
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Furthermore, the memantine-mediated inhibition on 4-AP-evoked glutamate release could be diminished by the protein kinase C (PKC) inhibitors, and memantine significantly reduced the depolarization-induced phosphorylation of PKC, and PKCalpha. | Memantine | protein kinase C, alpha | Rattus norvegicus |
| 2 | Furthermore, the memantine-mediated inhibition on 4-AP-evoked glutamate release could be diminished by the protein kinase C (PKC) inhibitors, and memantine significantly reduced the depolarization-induced phosphorylation of PKC, and PKCalpha. | Memantine | protein kinase C, alpha | Rattus norvegicus |
| 3 | Furthermore, the memantine-mediated inhibition on 4-AP-evoked glutamate release could be diminished by the protein kinase C (PKC) inhibitors, and memantine significantly reduced the depolarization-induced phosphorylation of PKC, and PKCalpha. | Memantine | protein kinase C, alpha | Rattus norvegicus |
| 4 | Furthermore, the memantine-mediated inhibition on 4-AP-evoked glutamate release could be diminished by the protein kinase C (PKC) inhibitors, and memantine significantly reduced the depolarization-induced phosphorylation of PKC, and PKCalpha. | Memantine | protein kinase C, alpha | Rattus norvegicus |
| 5 | Furthermore, the memantine-mediated inhibition on 4-AP-evoked glutamate release could be diminished by the protein kinase C (PKC) inhibitors, and memantine significantly reduced the depolarization-induced phosphorylation of PKC, and PKCalpha. | Memantine | protein kinase C, alpha | Rattus norvegicus |
| 6 | Thus, the effect of memantine on evoked glutamate release is linked to a decrease in [Ca2+]i contributed by Ca2+ entry through presynaptic voltage-dependent Ca2+ channels and to the subsequent suppression of the PKC signaling cascade. | Memantine | protein kinase C, alpha | Rattus norvegicus |