Title : A systematic review and economic evaluation of the clinical effectiveness and cost-effectiveness of aldosterone antagonists for postmyocardial infarction heart failure.

Pub. Date : 2010 May

PMID : 20492762






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1 The new decision model indicated that eplerenone was the most cost-effective strategy for postMI HF (ICER of eplerenone compared with standard care was 4457 pounds per QALY, increasing to 7893 pounds per QALY if treatment continued over the patient"s lifetime); in neither scenario did spironolactone appear cost-effective. Eplerenone cAMP responsive element modulator Homo sapiens
2 The new decision model indicated that eplerenone was the most cost-effective strategy for postMI HF (ICER of eplerenone compared with standard care was 4457 pounds per QALY, increasing to 7893 pounds per QALY if treatment continued over the patient"s lifetime); in neither scenario did spironolactone appear cost-effective. Eplerenone cAMP responsive element modulator Homo sapiens
3 The ICER of eplerenone was consistently under the 20,000-30,000 pounds per QALY threshold used to establish value for money in the NHS. Eplerenone cAMP responsive element modulator Homo sapiens