Title : Simultaneously entry of palmitic acid into proteolipid protein in different myelin subfractions of rat brain.

Pub. Date : 1984

PMID : 20488092






4 Functional Relationships(s)
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1 Rats of 20-days of age were injected intracranially with radioactive palmitic acid to study its incorporation into proteolipid protein (PLP) of myelin and myelin subfractions. Palmitic Acid proteolipid protein 1 Rattus norvegicus
2 At short times (120 min), the radioactivity present in PLP was shown to be due to palmitic acid bound to the protein by ester linkages. Palmitic Acid proteolipid protein 1 Rattus norvegicus
3 The specific radioactivity of palmitic acid labeled PLP was identical in all the myelin subfractions except the myelin-like fraction, in which it was lower, suggesting that the entry of the fatty acid into PLP of the different subfractions occurs simultaneously. Palmitic Acid proteolipid protein 1 Rattus norvegicus
4 Experiments using time staggered injections of (14)C- and (3)H-labeled palmitic acid also showed that entry of the fatty acid into PLP of the various subfractions was simultaneous. Palmitic Acid proteolipid protein 1 Rattus norvegicus