Pub. Date : 2010 May 19
PMID : 20483342
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The activities of ADF/cofilins are regulated by membrane phospholipid PI(4,5)P(2) in vitro and in cells, but the mechanism of the ADF/cofilin-PI(4,5)P(2) interaction has remained controversial. | pi(4,5)p | cofilin 1 | Homo sapiens |
| 2 | Our analysis revealed that cofilin does not harbor a specific PI(4,5)P(2)-binding pocket, but instead interacts with PI(4,5)P(2) through a large, positively charged surface of the molecule. | pi(4,5)p | cofilin 1 | Homo sapiens |
| 3 | Consequently, interactions of cofilin with membranes and actin exhibit sharp sensitivity to PI(4,5)P(2) density. | pi(4,5)p | cofilin 1 | Homo sapiens |