Title : Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation.

Pub. Date : 2010 May 19

PMID : 20482831






2 Functional Relationships(s)
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1 Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation. Dimethyl Fumarate interleukin 6 Homo sapiens
2 RESULTS: Pretreatment with DMF decreased synthesis of the proinflammatory mediators iNOS, TNF-alpha, IL-1beta and IL-6 at the RNA level in activated microglia and astrocytes in vitro, associated with a decrease in ERK phosphorylation in microglia. Dimethyl Fumarate interleukin 6 Homo sapiens