Title : Dopamine D2 receptor signaling modulates mutant ataxin-1 S776 phosphorylation and aggregation.

Pub. Date : 2010 Aug

PMID : 20477910






2 Functional Relationships(s)
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1 Activation of PKA by forskolin resulted in an enhanced S776 phosphorylation and increased ataxin-1 nuclear aggregation, which was suppressed by treatment with D2R agonist bromocriptine and PKA inhibitor H89. Colforsin ataxin 1 Mus musculus
2 Furthermore, treating SCA1 transgenic PC slice cultures with forskolin induced neurodegenerative morphological abnormalities in PC dendrites consistent with those observed in vivo. Colforsin ataxin 1 Mus musculus