Pub. Date : 2010 Aug
PMID : 20477760
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We demonstrate that WRNp localizes to the Oct4 promoter during retinoic acid-induced differentiation of human pluripotent cells and associates with the de novo methyltransferase Dnmt3b in the chromatin of differentiating pluripotent cells. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |
| 2 | The lack of DNA methylation was associated with continued, albeit greatly reduced, Oct4 expression in WRN-deficient, retinoic acid-treated cells, which resulted in attenuated differentiation. | Tretinoin | POU class 5 homeobox 1 | Homo sapiens |