Pub. Date : 2010 Nov 1
PMID : 20472336
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells. | Curcumin | tumor protein p53 | Homo sapiens |
| 2 | Curcumin killed wild-type p53 HCT-116 cells and mutant p53 HT-29 cells in a dose- and time-dependent manner. | Curcumin | tumor protein p53 | Homo sapiens |
| 3 | Curcumin killed wild-type p53 HCT-116 cells and mutant p53 HT-29 cells in a dose- and time-dependent manner. | Curcumin | tumor protein p53 | Homo sapiens |
| 4 | Similar results were obtained when the cytotoxic effect of curcumin was assessed in wild-type p53 HCT-116 cells after siRNA-mediated p53 knockdown. | Curcumin | tumor protein p53 | Homo sapiens |
| 5 | Similar results were obtained when the cytotoxic effect of curcumin was assessed in wild-type p53 HCT-116 cells after siRNA-mediated p53 knockdown. | Curcumin | tumor protein p53 | Homo sapiens |
| 6 | Chromatin condensation, poly (ADP-ribose) polymerase-1 cleavage and reduced pro-caspase-3 levels in curcumin-treated p53(+/+) and p53(-/-) HCT-116 cells suggested that curcumin caused apoptosis. | Curcumin | tumor protein p53 | Homo sapiens |
| 7 | In addition, exposure to curcumin resulted in superoxide anion production and phosphorylation of oxidative stress proteins in p53(+/+) and p53(-/-) HCT-116 cells. | Curcumin | tumor protein p53 | Homo sapiens |
| 8 | In addition, exposure to curcumin resulted in superoxide anion production and phosphorylation of oxidative stress proteins in p53(+/+) and p53(-/-) HCT-116 cells. | Curcumin | tumor protein p53 | Homo sapiens |