Title : Pentoxifylline improves haemoglobin and interleukin-6 levels in chronic kidney disease.

Pub. Date : 2010 Apr

PMID : 20470305






6 Functional Relationships(s)
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1 Pentoxifylline improves haemoglobin and interleukin-6 levels in chronic kidney disease. Pentoxifylline interleukin 6 Homo sapiens
2 AIM: To assess whether pentoxifylline improves anaemia of chronic kidney disease (CKD) via suppression of interleukin-6 (IL-6) and improved iron mobilization. Pentoxifylline interleukin 6 Homo sapiens
3 AIM: To assess whether pentoxifylline improves anaemia of chronic kidney disease (CKD) via suppression of interleukin-6 (IL-6) and improved iron mobilization. Pentoxifylline interleukin 6 Homo sapiens
4 In experimental models, pentoxifylline was shown to reduce IL-6 expression. Pentoxifylline interleukin 6 Homo sapiens
5 Treatment with pentoxifylline reduced circulating IL-6 (6.6 + or - 1.6 pg/mL, P < 0.01), increased transferrin saturation (20 + or - 5%, P < 0.003) and decreased serum ferritin (81 + or - 25 microg/L, P = NS). Pentoxifylline interleukin 6 Homo sapiens
6 CONCLUSIONS: Pentoxifylline reduces circulating IL-6 and improves haemoglobin in non-inflammatory moderate to severe CKD. Pentoxifylline interleukin 6 Homo sapiens