Title : Protein kinase C epsilon regulation of translocator protein (18 kDa) Tspo gene expression is mediated through a MAPK pathway targeting STAT3 and c-Jun transcription factors.

Pub. Date : 2010 Jun 15

PMID : 20469933






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The MEK1/2 specific inhibitor U0126, but not NFkappaB inhibitors, reduced basal Tspo promoter activity in TSPO-rich steroidogenic cells (MA-10 Leydig), as well as basal and PMA-induced Tspo promoter levels in TSPO-poor nonsteroidogenic cells (NIH-3T3 fibroblasts). U 0126 mitogen-activated protein kinase kinase 1 Mus musculus