Pub. Date : 2010 Sep
PMID : 20467834
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The opioid agonist methadone has previously been demonstrated to inhibit hERG currents, and there are reports of serious cardiac arrhythmias and deaths from TdP and ventricular fibrillation in patients taking methadone. | Methadone | ETS transcription factor ERG | Homo sapiens |
| 2 | The opioid agonist methadone has previously been demonstrated to inhibit hERG currents, and there are reports of serious cardiac arrhythmias and deaths from TdP and ventricular fibrillation in patients taking methadone. | Methadone | ETS transcription factor ERG | Homo sapiens |
| 3 | The aim of the present study was to compare the effects of the opioid agonists methadone and heroin (3,6-diacetylmorphine) on hERG currents stably expressed in human embryonic kidney (HEK 293) cells using the whole-cell configuration of the patch-clamp technique. | Methadone | ETS transcription factor ERG | Homo sapiens |
| 4 | Both methadone and heroin inhibit hERG currents in a concentration-dependent manner. | Methadone | ETS transcription factor ERG | Homo sapiens |
| 5 | In conclusion, the potency for block of hERG currents is about 100-fold lower for heroin when compared to methadone. | Methadone | ETS transcription factor ERG | Homo sapiens |